The study examined specific immune pathways known to be activated during flu infections in both humans and mice, which makes the findings relevant to children. (sciencedaily.com)
The critical immune pathway in question is the NOD2 pathway, which detects and responds to bacterial invaders by releasing inflammatory signals to fight the infection. (sciencedaily.com)
In addition to its critical host defense role, NADPH oxidase also functions to restrain inflammation by modulating redox - sensitive innate immune pathways during infection and injury. (roswellpark.org)