Scientists in pursuit of an HIV vaccine are building on this work, designing techniques to elicit these antibodies through sequential stimulation of the immune system with specifically designed immunogens. (sciencedaily.com)
A Genome - Wide Proteome Array Reveals a Limited Set of Immunogens in Natural Infections of Humans and White - Footed Mice with Borrelia burgdorferi (pnas.org)
Thus the GL VHH tested in this study which both bind the R2 immunogen and neutralize the corresponding virus were not present at t = 54 at detectable level by 454 sequencing and it is therefore likely that they were absent or extremely rare at t = 0. (journals.plos.org)