The phrase "immunosuppressive effects" refers to the ability of something to weaken or suppress the immune system. It means that it can reduce the ability of the immune system to fight off infections or tackle diseases effectively. Full definition
However, for GVHD, the use of MSCs is a double - edged sword, because the prevention of GVHD was associated with a high incidence of leukaemia relapse, which is the result of the non-specific immunosuppressive effect of MSCs on graft - versus - leukaemia 57, 58. (cellr4.org)
Last, CD34 + cells from T1D patients were pharmacologically treated to increase PD - L1 expression, and these modulated cells demonstrated an enhanced immunosuppressive effect in vitro. (immunology.sciencemag.org)
Luznik and colleagues have sought the right balance by giving high doses of cyclophosphamide, a chemotherapy drug with immunosuppressive effects, shortly after transplantation. (sciencemag.org)