Further, research from our clinic has demonstrated excellent reliability for the ADIS with interrater agreement of kappa = 1.00 for an overall anxiety disorder diagnosis, and between Kappa =.80 and.93 for specific anxiety diagnoses (Lyneham et al. 2007). (link.springer.com)
Unlike SSRIs which target the serotonin system in the brain, BU10119 works by blocking receptors called kappa opioid receptors. (sciencedaily.com)
Within her wider interest, Dr. Chartoff's laboratory focuses on sex differences in molecular and genetic contributions to addictive behaviors, the role of glutamatergic transmission in affective states and the role of kappa opioid receptors in drug withdrawal - induced depressive - like states. (mcleanhospital.org)