Using mouse genetics in combination with novel sequencing technologies our lab is able to identify key cell types or candidate factors important for specific remodeling and repair processes of the heart. (hubrecht.eu)
The team found deep conservation of certain processes that likely reflects similar underlying regulatory processes between mouse and man, but there were also significant differences in gene expression during kidney development, as well as in the timing, scale, organization, and molecular profile of key cell types and cell structures. (sciencedaily.com)
For example, cross-model comparisons may help to pinpoint key cell types and molecules involved in lineage decisions, reveal evolutionary inventions, and may allow to interpret genetic disease models (for example in mouse) by mapping to human or other systems. (humancellatlas.org)