While the process usually proceeds in a one - way direction, artificially inducing the activity of key transcription factors can reprogram differentiated cells back into a stem - like state, a discovery honored with the 2012 Nobel prize. (sciencedaily.com)
Austin Smith of the Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute teamed up with investigators from the Microsoft Research Computational Science Laboratory, also in the U.K., to incorporate experimental data on 20 key transcription factors involved in stem cell self - renewal. (the-scientist.com)
What are the direct targets of key transcription factors that regulate cardiogenesis and cardiomyocyte differentiation and how do they function in networks? (gladstone.org)