In this condition, hereditary kidney abnormalities can lead to premature kidney failure and death. (soonervet.net)
Mouse mutants of BicC1 develop kidney abnormalities reminiscent of Polycystic Kidney Disease. (lerner.ccf.org)
Generally, sickle cell trait (when only one copy of the mutation is present) is thought to be benign, but kidney abnormalities have been reported in some affected individuals. (sciencedaily.com)