Phrases with «kinase domain»

The phrase "kinase domain" refers to a specific part or region of a protein called a kinase. Kinases are enzymes that help regulate and control various cellular processes by adding a phosphate group to other molecules. The kinase domain is the part of the kinase protein that carries out this phosphorylation process. It acts like a molecular machine, attaching phosphate groups to specific targets, which helps to activate or deactivate certain cellular pathways and signals. Full definition

kinase domain

Sentences with «kinase domain»

This work, and that of colleagues Brian Druker and Novartis, led to the development of the kinase inhibitor imatinib (Gleevec) as primary therapy for chronic myelogenous leukemia (CML), and the discovery that imatinib resistance is caused by BCR - ABL kinase domain mutations. (thecolumngroup.com)
To visualize the Phe958 to Val mutation, we used the crystal structure of the JAK1 kinase domain with CMP6 inhibitor (Figure 2C). (haematologica.org)
WEHI - 435 was obtained by analysis of the RIPK2 / ponatinib structure and the necrostatin - 1 / murine RIPK1 structure to obtain a structural face for the murine RIPK2 kinase domain (18 — 249)(Nachbur et al., 2015). (jpet.aspetjournals.org)
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Phrases with «kinase domain»

Sentences with «kinase domain»

See also