Research suggests that niacinamide participates in the serotonin - producing kynurenine pathway and stimulates GABA receptors to help reduce nervous tension and support a calm and relaxed mood. (mossnutrition.com)
By lowering circulating levels of kynurenine in the body, the brain is protected from stress - induced biochemical changes that could otherwise lead to depression. (blog.addgene.org)
Indoleamine 2,3 - dioxygenase (IDO1) is an enzyme that catalyze the transformation of the amino acid tryptophan in kynurenine. (iteostherapeutics.com)