The researchers found that p53 limits invasion by initiating a chain of events that ultimately prevents the formation of lamellipodia, cell membrane protrusions that spur cell movement and invasion. (sciencedaily.com)
With low levels of active p130Cas, cells don't form lamellipodia and are therefore less able to invade. (sciencedaily.com)
«The targeted nanorods tied up the integrin and blocked its functions, so it could not keep guiding the cytoskeleton to overproduce lamellipodia and filopodia,» said Yan Tang, a postdoctoral assistant in computational biology who worked on the study. (sciencedaily.com)