The role of Smurf1 — one of hundreds of E3 ubiquitin ligases in mammals — was unknown in this process. (sciencedaily.com)
Hsia HE, Takeda M, Courchet J, Goebbels S, An W, Eickholt B, Polleux F, Rotin D, Wu H, Nave KA, Rossner M, Brose N, Kawabe H. (2014) The Ubiquitin E3 Ligase Nedd4 - 1 acts as a downstream target of PI3K / PTEN - mTORC 1 signaling to promote neurite outgrowth. (polleuxlab.com)
We are especially interested in the role of Cullin - RING complexes, the largest class of E3 ubiquitin ligases in eukaryotes. (hubrecht.eu)