The difference doesn't really matter for your personal use, but some applications just need a folder to write to because they don't have access to the main Local folder. (howtogeek.com)
To navigate there, right click To the Moon from Steam library — Property — Local Files — Open Local Folder. (freebirdgames.com)
A reversible local folding step in which a duplex docks and undocks from the ribozyme core was observed directly in single - molecule time trajectories, allowing the determination of the rate constants and characterization of the transition state. (science.sciencemag.org)