A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2. (semanticscholar.org)
Not only did APP accumulate in lysosomes of mice lacking NEU1 but researchers found evidence that the build - up promoted the production of Aβ - 42 and other toxic peptides tied to Alzheimer's disease. (stjude.org)
Autophagosome sequesters the degradative targets, whose process is followed by fusion with lysosomes for degradation of its contents. (sciencedaily.com)