The team also showed that the cellular process macropinocytosis, which participates in cell scavenging nutrients and vesicles, contributes to exosomes uptake in cancer cells with mutant KRAS. (sciencedaily.com)
Further study is needed to gain a better understanding about whether exosomes entering cells via macropinocytosis have other features that could enhance their anti-tumor capabilities.» (sciencedaily.com)
«The increased number of exosomes reaching the pancreas may gain further advantage to enter KRAS - associated cancer cells as a result of enhanced macropinocytosis, which concurs with previous findings,» said Kamerkar. (sciencedaily.com)