Use a perforated nesting meatloaf pan if you've got one so that the fat drains out into the pan below. (topsecretrecipes.com)
6) If you use a meatloaf pan when you pull the pan out of the oven, you can run a butter knife around the edges, especially if there's any fat that pooled around the top and didn't drip down. (amandascookin.com)