Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation. (nature.com)
The population - based study of 503 people with colon cancer found that 14 percent of Caucasians and 7 percent of African - Americans had a genetic marker called microsatellite instability, or MSI. (sciencedaily.com)
Both cancer types demonstrate a high frequency of microsatellite instability, where the repair mechanism for DNA is broken, and mutations in POLE, a gene responsible for producing a protein involved in DNA replication and repair. (genome.gov)