They also identified the domains involved in multimerization, suggesting drug targets for slowing tumor progression. (asbmb.org)
Using clinical brain tumor samples, Natalia Filippova and colleagues at the University of Alabama show in a paper in the Journal of Biological Chemistry that increasing tumor severity was associated with increased multimerization and aggregation of HuR. (asbmb.org)
However, such multimerization capabilities should not interfere with the intended goal of non-toxically labeling cells for deep tissue and intravital imaging as the Amrose variants 1 — 3 were developed in vertebrate cells. (journals.plos.org)