They rapidly become space - occupying and start to crowd out normal bone marrow cells that otherwise would develop into healthy, mature red and white blood cells. (petwave.com)
In normal bone marrow, stem cells produce red blood cells that carry oxygen, white blood cells that protect the body from infection, and platelets that are involved in blood clotting. (sbnation.com)
In humans, a comparison of bone marrow from 14 normal bone marrow donors, 35 multiple myeloma patients and 11 patients with a noncancerous condition called monoclonal gammopathy of undetermined significance (MGUS) showed that Runx2 levels were significantly higher in the multiple myeloma cells. (sciencedaily.com)