Changes in obliquity modulate seasonal contrasts as well as annual mean insolation changes with opposite effects at low vs. high latitudes (and therefore no effect on global average insolation)-LCB- 6.4 -RCB-. (ipcc.ch)
Now the glacial cold lurking in the deep ocean, held in check by obliquity for 10,000 years, has been set free, ending the Holocene Interglacial. (judithcurry.com)
I would hazard a guess that during periods of high obliquity that ozone holes have naturally developed. (theinconvenientskeptic.com)