The application of next - gen sequencing to RNA libraries (RNA - Seq), chromatin immunoprecipitates (CHiP - Seq), bisulfite - treated DNA, and regions of open chromatin (DNAse - Seq) makes it possible to interrogate many aspects of the genome in high - throughput fashion. (massgenomics.org)
Additionally, we found that DNA loss events tended to be smaller than DNA gain events suggesting that they were able to accumulate in gene - rich open chromatin regions due to their reduced capacity to interrupt gene regulatory architecture. (journals.plos.org)
At sites of UV damage, E2F1 recruits the histone acetyltransferase GCN5, which acetylates histone H3K9 in order to open chromatin structure and increase accessibility to the damaged site by the DNA repair machinery. (mdanderson.org)