This first - pass by the liver makes supplementing with oral hormones difficult. (drkaslow.com)
«Older age at menopause and use of hormone therapy produce increased risk of hearing loss: Unexpected results of new study show higher risk of hearing loss when using oral hormone therapy for longer duration.» (sciencedaily.com)
Six years later, the number of women using oral hormone therapy had sunk below 5 percent. (sciencenews.org)