These findings reveal a function for ABL kinases in the regulation of breast cancer bone metastasis and tumor - induced osteolysis in vivo. (stke.sciencemag.org)
Moreover, three - dimensional (3D) μCT reconstruction of the tibia revealed that mice injected with control cells had a significantly higher degree of osteolysis with a decreased ratio of bone volume to total volume compared to mice injected with ABL1 / ABL2 knockdown breast cancer cells (Fig. 4, E and F). (stke.sciencemag.org)
We demonstrated that ABL kinases promoted tumor - induced osteolysis in part through the osteoclast - activating cytokine IL - 6, increased serum concentrations of which are associated with poor clinical outcome in breast cancer patients (50). (stke.sciencemag.org)