If they exceed 3 to 4 days without relieving themselves, or display other abnormal behavior, you should consult your vet to see if there is a deeper health problem. (stantonpethospital.com)
If your pet gets distressed, becomes nervous, or demonstrate other abnormal behavior, just let go in their «birthday suit». (bellshoalsanimalhospitalbrandon.com)
Some will stagger, appear disoriented, or exhibit other abnormal behaviors. (thesprucepets.com)