Studies have shown that prolonged OS is one of the main factors involved in ovarian aging. (nicolejardim.com)
Changes in the ovarian microenvironment, such as reduced oxygen supply to the growing follicles are likely causes of ovarian aging, according to Patrizio. (sciencedaily.com)
Additionally, the immune system of a woman with autoimmunity can also attack her own ovaries and cause Premature Ovarian Aging (POA) and / or PCOS. (mindbodygreen.com)