The U.S. Public Health and Marine Hospital Service — soon to be known as the Public Health Service (PHS), a precursor to the National Institutes of Health — began studying pellagra in 1909. (discovermagazine.com)
Lysine deficiency can result in vitamin B3 (niacin) deficiency and this can cause a disease called pellagra [7]. (nutrientsreview.com)
Vitamin B3 deficiency lasting for few months [7] causes pellagra (Italian pella agra = rough skin) with «four D» symptoms: dermatitis with burn - like blisters and later rough, scaly and painful, but not itchy, lesions on the sun - exposed areas (face, extension side of the hands / arms and leg / feet), diarrhea, dementia and death (if not treated)[1]. (nutrientsreview.com)