Applying these methods to prostate cancer cell lines, the researchers found that accurate predictions of drug sensitivity could be achieved using either genomics data or phosphoproteomics data alone. (sciencedaily.com)
This visual abstract depicts how Wei et al. utilize single - cell phosphoproteomic analysis of patient derived glioblastoma models to identify shifts in signaling coordination following short - term treatment with kinase inhibitors, which facilitates the design of combination therapy approaches with reduced resistance and improved efficacy. (sciencedaily.com)
Proteomics and phosphoproteomics analyses in melanoma cells identified CDK2 as a driver of resistance to both BRAF and Hsp90 inhibitors. (scilifelab.se)