Moreover, estrogen can exert direct effects on fat tissue by enhancing proliferation of preadipocytes, especially in females (232), and by up - regulating sc α2A - adrenergic receptors promoting SAT accumulation, notably in premenopausal women (233). (academic.oup.com)
Yang J. Berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokines profile in human preadipocytes and metabolic syndrome patients. (pcosnutrition.com)