Progressive decreases in serum cobalamin concentration in dogs with asymptomatic SIBO often precede development of clinical signs. (epi4dogs.com)
In the first stage of Renal Dysplasia, there is a silent and progressive decrease in kidney function over months, or even years. (pedigree.com)
With the progressive maturation of Lob 1 to Lob 2, Lob 3, and Lob 4 there is a progressive decrease in the percentage of proliferating cells, a reduction in the percentage of cells positive for steroid hormone receptors, and a reduction in the susceptibility of the cells to be transformed by chemical carcinogens [47]. (breast-cancer-research.biomedcentral.com)