Malanchi and colleagues reported in Figures 3A and S13A that POSTN does not affect the size of the primary tumors, but MMTV - PyMT + / tg; Postn − / − mice develop significantly fewer metastases than their Postn + / + counterparts (Malanchi et al., 2012). (elifesciences.org)
Inhibition of the tyrosine phosphatase Shp2 in breast cancers of PyMT mice induces senescence. (sciencedaily.com)
The studies reported in the present study demonstrate that Slc6a14 plays an important role in promoting the development and growth of PyMT - driven and Neu - driven mammary tumours in mice. (biochemj.org)