No data are yet available for trials in children, who typically have much less robust immune responses to the seasonal influenza vaccine and require a second dose. (sciencemag.org)
Additionally, this approach has the potential to stimulate a more robust immune response through an adjuvant effect of the immune mismatch between AST - VAC2 and patients. (asteriasbiotherapeutics.com)
The researchers manufactured a mutant influenza virus that is susceptible to one of the body's primary immune defense mechanisms and has generated induced robust immune responses in animal models. (immunology.org)