But sleep - deprived mice that received shots of rolipram after their training remembered just as well as well - rested animals, the scientists report tomorrow in Nature. (sciencemag.org)
Applying rolipram to brain slices from sleep - deprived mice restored LTP. (sciencemag.org)
To confirm that extra enzyme led to sleep deprivation's effects on memory, the scientists next tried to counteract it with rolipram, a drug that inhibits PDE4A5 and other similar PDEs. (sciencemag.org)