"Ruination" refers to the act or state of completely destroying or causing extreme harm to something or someone. It suggests severe damage or ruin, often leading to a state of irreversible destruction. Full definition
This government has been exposed as failures and fraudsters, and firmly responsible for the continued ruination of our economy. (politics.co.uk)
The company is best known for its hop - intense pale ales, such as Ruination and the «Enjoy By» line, which encourages holders to consume the beer by a certain date for maximum freshness. (fortune.com)
Then, like now, breeder of true performance dogs knew that the show ring spelled ruination for their animals. (workingpitbull.com)