These findings support a role for the ABL kinase — STAT5 signaling axis in breast cancer metastasis. (stke.sciencemag.org)
The binding of a BRAF mutation to the ER stress gatekeeper GRP78 is a new and unexpected molecular interaction driving resistance, and establishes a new signaling axis that has multiple drug targets, Dr. Amaravadi said. (sciencedaily.com)
«Our work shows that the PKCepsilon / Nanog / Bmi1 signaling axis is essential to promote head and neck cancer,» Pan says. (sciencedaily.com)