Main chain carbonyl oxygen atoms from the K + channel signature sequence line the selectivity filter, which is held open by structural constraints to coordinate K + ions but not smaller Na + ions. (science.sciencemag.org)
Genomics in the search for novel signature DNA sequences: We are using our combined expertise on evolutionary phylogeny, prokaryote cell physiology and comparative genomics to identify new signature sequences. (cmbn.no)
They then cultured bacteria from the site and isolated the strain whose DNA matched their signature sequence, they report online this week in the Proceedings of the National Academy of Sciences. (sciencemag.org)