Any time you cut calories, you're going to experience some of these effects, but they tend to be less severe with smaller deficits. (completehumanperformance.com)
Smaller deficits tend to cause fewer changes, both positive and negative, and larger deficits tend to do the opposite. (completehumanperformance.com)
Larger deficits also tend to cause a greater drop in leptin, thyroid, and other hormones while smaller deficits have a smaller impact. (completehumanperformance.com)