In breeds with small gene pools, as is the case with many pure breeds, elimination of identified carriers may not be the best strategy, as genetic diversity would become dangerously compromised. (thedogplace.org)
In general, pedigree breeds use a much smaller gene pool for breeding than domestic cats and therefore have a higher risk of developing inherited disorders. (icatcare.org)
Like other breeds with a very small gene pool, some of these issues may be compounded and widespread. (havanesefanciers.com)