Plaque hinders neuronal activity by gumming up synapses (spaces between cells through which chemical or electrical information is transmitted), eventually damaging nerve cell branches and leading to neuronal death. (scientificamerican.com)
Across the tiny spaces between the cells, known as synapses, molecules called neurotransmitters ferry messages back and forth. (discovermagazine.com)
The lymphatic system also removes excess fluid, and waste products from the interstitial spaces between the cells. (lymphnotes.com)