We developed and implemented such a nomenclature for the European human pluripotent stem cell registry (hPSCreg), which needs to: 1) unambiguously identify a registered cell line; 2) allow tracing of subclones of a particular line; and 3) enable the assignment of different lines to a specific donor origin. (hpscreg.eu)
Because epigenetic changes affect gene activity, the research team categorized the affected genes by function to see if the changes might have specific consequences among different subclones from the same patient. (sciencedaily.com)
Patients often have multiple versions of the cancer, called subclones, which have different mutations, and the researchers wanted to find if the expression levels of RNA correlated with the different mutations. (sciencedaily.com)