In a second paper, also published online today in Nature, developmental biologist Luis Parada and his colleagues at the University of Texas Southwestern Medical Center (UTSMC) in Dallas show that in mice that develop glioma, a form of brain cancer, tumor growth seems to come from a small subset of cells in the tumor. (sciencemag.org)
Second, the AAV preps generally used for gene editing are low titre, and are therefore able to infect only a small subset of the cells used in a given experiment. (blog.addgene.org)
There it correlates with gene repression, but likely only in distinct subsets of cells within each organ, (see Schultz et al., 2015). (alzforum.org)