The fat stored in your body can produce estrogen (which can also lead to breast cancer) or proteins that cause inflammation and insulin resistance, resulting in tumor cell growth. (mindbodygreen.com)
In humans, this mutation hyper - activates tumor cell growth, telling cancer cells to grow continuously. (vet.osu.edu)
Damage occurs when metastatic tumor cells recruit pre-osteoclast cells to the bone and then induce their differentiation into mature bone - degrading cells, which results in the release of proteins from the bone matrix that promote tumor cell growth. (science.sciencemag.org)