When pounds of tumor die, the dead cancer cells have to be cleared out of the body, and special medical procedures are required to prevent that from resulting in toxicities such as kidney failure and other problems from the metabolic effects of tumor destruction. (cancerresearch.org)
The team found that high - aneuploidy tumors had increased expression of genes implicated in DNA replication, cell cycle, mitosis, and chromosome maintenance, yet decreased expression of genes characteristic of the infiltrating immune cells responsible for tumor destruction. (sciencedaily.com)
The key to this approach is minimizing healthy tissue damage while maximizing cancerous tumor destruction of the sort that improves recognition of the tumor by the immune system. (sciencedaily.com)