The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene. (abcam.com)
Mutations of the VHL tumour suppressor gene in renal carcinoma. (jcancer.org)
The task is large but not insurmountable, says Rebecca: «One of the big problems with this cancer is that it doesn't have a recurrent driver gene — it's a disease dominated much more by multiple tumour suppressor genes being lost. (cancerresearchuk.org)