The findings, published November 28 in Scientific Reports, offer a better understanding of the motions and functions of efflux pumps. (sciencedaily.com)
We thought, if the latter scenario is operative, then a molecule comprising the minimal portion of the ADEP that is recognized by the pump could competitively interfere with efflux of the ADEP.» (sciencedaily.com)
This hypothesis was supported by our observation of increased levels of expression of several influx transporters (Oat2, Oct3, Octn1, and Oatp3) after 4 weeks and again at 16 weeks, positioning their changes before and during the increases in efflux transporters (Abcb1, Abcb8, Abcb9, Abcc5, and Abcc10) that occurred mainly at 8 and 16 weeks. (academic.oup.com)