A similar mutation, detected by S1 nuclease mapping of LDL receptor messenger RNA, occurred in a patient with familial hypercholesterolemia whose receptor also fails to be transported to the cell surface. (science.sciencemag.org)
[9] One study showed that consuming 2 g of plant sterols reduces the concentration of LDL - C in individuals with hypercholesterolemia by more than 10 % after 12 months. (naturopathiccurrents.com)
The approach described by the Nantes team thus generates clinically relevant models of hypercholesterolemia that can be used to predict pharmacological responses, paving the way to personalize the treatment of high - risk patients. (sciencedaily.com)