Previous work led by Charlotte Kuperwasser, principal investigator, determined that some common forms of breast cancer originate from luminal cells while some rarer forms of breast cancer originate from basal cells. (sciencedaily.com)
Notably, in mice bearing breast cancer cell line - derived tumors, administration of OTSSP167 significantly impaired the growth of basal breast tumors, or even caused tumor regression; by contrast, the growth of luminal tumors were largely unaffected by the treatment (Figure 7E, 7F). (elifesciences.org)
They found that a small number of genes are activated by STAT3 protein signaling in basal - like breast cancers but not in luminal breast cancers. (sciencedaily.com)