Spinosad is a derivative of macrolide antibiotics Spinosad attacks the nervous system of the flea acting on the nicotinic acetylcholine receptors, there is no interaction with other insecticides. (safarivet.com)
In E. coli, MphR can detect the presence of macrolide antibiotics being secreted by microbes that are attacking E. coli. (sciencedaily.com)
Combining the microfilaria and adult antigen test is most useful in dogs receiving diethylcarbamazine or no preventative (as macrolides as for example ivermectin or moxidectin typically render the dog amicrofilaremic). (en.wikipedia.org)