They also have traits resembling those found in obese humans, including heart problems, lying around not exercising, and poor sleeping habits. (unlv.edu)
But when injected into hundreds of obese human volunteers, leptin's effect was clinically insignificant. (discovermagazine.com)
In obese humans, substitution of carbohydrate with protein leads to far greater weight loss, nearly twice as much. (paleodiabetic.com)