This bizarre shift of tissue systems, known as heterotopic ossification in most cases, can be brought on with spinal cord injury, amputation and even hip surgery. (scientificamerican.com)
The receptor is important for the process of endochondral ossification, in which the cartilage cells first proliferate, and are then replaced by bone tissue. (sciencedaily.com)
«Our study provides profound insight into the role of cellular hypoxia in FOP flare - ups and shows that cellular oxygen sensing through HIF - 1α is a critical regulator of the BMP pathway and heterotopic ossification in FOP,» Kaplan said. (sciencedaily.com)