Sentences with phrase «+ cytotoxic»

We also investigate the mechanisms that in dendritic cells allow for early endosomal escape of antigens leading to subsequent crosspresentation to CD8 + cytotoxic T lymphocytes.

Precursors of human CD4 + cytotoxic T lymphocytes identified by single - cell transcriptome analysis.

In addition, studies showed that the elimination of residual leukemia was primarily mediated by donor CD8 + cytotoxic T lymphocytes and NK cells, whereas the inflammatory cytokines that are secreted mainly by CD4 + Th cells have a very limited role in leukemia eradication but contribute significantly to the toxicity of GVHD (55).

Studies in CD8 knockout (KO) and perforin KO mice demonstrated that CD8 + cytotoxic T lymphocytes (CTL) are unnecessary for the rejection of corneal allografts in mice (8, 9).

Specifically, TheraT ® has proven to be safe in animals as well as capable of eliciting uniquely potent antigen - specific CD8 + cytotoxic T cell responses and strong tumor control in mice.

Human CD4 + cytotoxic T lymphocytes that play a vital role in antiviral immunity are highly heterogeneous.

In particular, they found significant expansion of CD3 + CD8 + cytotoxic T - cells and CD3 + CD4 + helper T - cells in circulating blood, as well as increased CD4 + subsets of Th1, Th2, Th17 and Treg cells, indicating a pro-inflammatory response.

Not exact matches

In healthy skin, CD49a + and CD49a cells are dormant, but quickly respond with inflammatory and cytotoxic effects when stimulated by IL - 15, a protein secreted from skin cells as a rapid - response defence against microbial attack.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

They induce CD4 + helper T cell responses, which in turn activate cytotoxic T cells and direct them to recognize and fight specific types of cancer.

Some of these T cells become «effectos» (the ones that have direct roles in the immune response, including helper functions for CD4 + T cells, and cytotoxic functions for CD8 + T cells), while other T cells differentiate into resting memory cells.

New research from La Jolla Institute for Allergy and Immunology lays the groundwork to parse how the virus interacts with its host and causes disease by pinpointing CD8 + T cells, a subset of T cells more commonly known as cytotoxic or killer T cells, as important gatekeepers that control Zika infection or limit the severity of disease.

Poliovirus - specific CD4 + Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor.

A Marked Reduction in Priming of Cytotoxic CD8 + T Cells Mediated by Stress - Induced Glucocorticoids Involves Multiple Deficiencies in Cross-Presentation by Dendritic Cells.

Moreover, there are yet other cell types — such as visceral adipose tissue macrophages and cytotoxic CD8 + T - cells — in which the age - related supernumerary accumulation of dysfunctional and apoptosis - resistant cells appears to play a highly deleterious role on tissue function, but where the cells are not «senescent» cells in the classical sense of p16Ink4a expression and the senescence - associated secretory profile observed in senescent fibroblasts.

SENS Foundation is funding ongoing work in the lab of Dr. Janko Nikolich - Zugich to investigate the effects of clearance of anergic, «senescent» cytotoxic CD8 + T - cells on immunosenescence, (22) and is interested in the targeting of other such cells.

The researchers demonstrated this by temporarily getting rid of the immune system's cancer - killing cells, called CD8 + or cytotoxic T cells, and showing that without these cells, the virus killed only the initial five percent of cancer cells.

Positive clones were then differentiated using defined serum - free conditions outlined in Ng, et al [7], which overall gave rise to a CD45 + CD56 + CD117 − CD94 + population of cytotoxic NK cells [8] expressing the CD4 construct and other surface markers in a similar manner to peripheral blood NK cells.

Inflammatory infiltrates were composed of CD8 +, CD4 +, CD3 +, CD5 + and, rarely, CD7 + lymphocytes, whereas B lymphocytes and T cytotoxic cells CD16, CD57, TIA and graenzyme were negative.

CD8 (+) cytotoxic and CD4 (+) helper / inducer T cells develop from common thymocyte precursors that express both CD4 and CD8 molecules.

g defined serum - free conditions outlined in Ng, et al [7], which overall gave rise to a CD45 + CD56 + CD117 − CD94 + population of cytotoxic NK cells [8] expressing the CD4 construct and other surface markers in a similar manner to peripheral blood NK cells.

CD8 + cells — also called cytotoxic T - lymphocytes (CTLs)-- matter because, among other actions, they kill cells that become infected with HIV.

Lymphocytes (T - cells = Thymic lymphocytes = killer T cells (aka CD8 +, cytotoxic T cells) & Helper T cells (aka CD4 +)-RRB- patrol the body constantly looking for suspicious invaders or unnecessary elements through the release of lymphokines.