Sentences with phrase «+ hematopoietic»

Lentiviral - based gene therapy methods to modify human CD34 + hematopoietic stem cells have been investigated as a way of treating various hematological disorders including X-linked chronic granulomatous disease (X-CGD).

Targeted Gene Addition to a Safe Harbor locus in human CD34 + Hematopoietic Stem Cells for Correction of X-linked Chronic Granulomatous Disease.

The chemokine receptor CXCR - 4 is expressed on CD34 + hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell - derived factor - 1.

One of the most popular models is the immunodeficient nonobese diabetic severe combined immunodeficiency (NOD scid) gamma (NSG) transgenic mouse line, which can be endowed with a humanized immune system using CD34 + hematopoietic stem cells.

Not exact matches

Following introduction into human CD4 + T cells [23] or hematopoietic stem cells [28] via an adenovirus vector or DNA nucleofection, respectively, the ccr5 gene was efficiently and specifically disrupted.

In addition, transgenic autologous hematopoietic stem cells can be successfully transplanted in HIV - infected individuals [18] and several phase I adoptive transfer trials of CD4 + T cells treated with R5 - ZFNs in HIV infected individuals are currently underway.

However, coreceptor - specific ZFNs represent a novel therapeutic approach to recapitulate this success via autologous transplantation of gene - modified hematopoietic stem cells and mature CD4 + T cells.

Hematopoietic stem cells (HSCs) can be isolated from the bone marrow and are characterized by the expression of Lin - CD34 + CD38 - CD90 + CD45RA -.

Bone marrow CD169 + macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche.

Generation of an HIV -1-resistant immune system with CD34 (+) hematopoietic stem cells transduced with a triple - combination anti-HIV lentiviral vector.

To understand the molecular basis of these observations, we analyzed global RNA splicing in Sf3b1 ^{K700E / +} hematopoietic cells.

Here, we exploit HOXB4, a hematopoietic transcription factor, to facilitate the derivation of large numbers of CD45 + cells, which were sorted and characterized.

Sf3b1 ^{K700E / +} animals had impaired erythropoiesis and progressive anemia without ringed sideroblasts, as well as reduced hematopoietic stem cell numbers and host - repopulating fitness.